As part of his commitment to the advancement of integrative medicine, Dr. Eliaz partners with leading research institutes and has co-authored numerous peer-reviewed papers on innovative therapies for immune enhancement, heavy metal toxicity and cancer prevention and treatment. That inflammation reaction is a key way that chronic stress leads to serious mood disorders such as anxiety and depression. Exclusive Lifestyle, Nutrition & Health Advice. Treasure Island (FL): StatPearls Publishing. With over 50 published studies and counting, researchers at Harvard, the NIH and other renowned institutes are increasingly interested in the singular ability of this MCP to halt and reverse the devastating actions of galectin-3, in cancer as well as heart disease, kidney failure, arthritis and much more. In cases of aggressive cancer, a more intensive treatment called Therapeutic Apheresis can also be used. While we may never completely eradicate cancer from this world, groundbreaking discoveries have the potential to give us the upper hand against this aggressive disease. Researchers found that a combination of tumor radiation and honokiol had the capability to reduce a mouse lung tumor by 78%. www.drweil.com, Worried About Your Blood Sugar Levels? These compounds, including magnolol and honokiol, have been studied extensively in recent years for their anti-inflammatory, anticancer, antimicrobial, and antioxidant benefits (1, 2, 4, 6, 7, 8). A study in mice found a magnolol dose of 2.30.9 mg per pound (525 mg per kg) of body weight significantly decreased sleep latency, or the amount of time it takes to fall asleep (27). It confuses your immune system so much that it triggers immune overreactions and under-reactions. Nevertheless, additional research in humans is needed. Scientific reports, 7, 45342. https://doi.org/10.1038/srep45342, Groves, Maria Noel, RH (AHG). The Physiomedical Dispensatory. Safety Class: 2b (Not to be used during pregnancy). Note that the numbers in parentheses (1, 2, etc.) Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. The bark of Magnolia oficinalis has been used in traditional Chinese medicine for centuries to address anxiety and nervous tension and to promote sleep. This article outlines an anti-inflammatory diet plan that is based on science. magnolia bark ( Magnolia officinalis) N-acetylcysteine probiotic ( Lactobacillus helveticus) tribulus ( Tribulus terrestris) This doesn't mean that these supplements won't have the same effects in humans, but it does mean that their effectiveness in humans has not yet been clinically proven. When alarm protein galectin-3 gets activated in response to stress, it kicks off a series of inflammatory reactions. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor. And part of that means better understanding galectin-3. The goal is to eliminate the disease and simultaneously restore health, and in my decades of research and working with patients, Ive seen many outcomes that other doctors would call miraculous. We call it simply, integrative medicine. More than 200 types of magnolia trees exist worldwide. Hospital affiliations include Hoag Memorial Hospital Presbyterian. This dried bark known for its sharp smell and bitter taste is then soaked in a traditional medicine tincture for oral use. Were making great strides in the treatment of cancer 16.9 million survivors in the United States can testify to that. When the body perceives itself to be under attack, it produces more galectin-3, which in turn triggers a cascade of inflammatory signals, all of which fuel cancer and chronic diseases. Unfortunately, you cant avoid stress completely. Aside from neolignans, more than 200 chemical compounds have been isolated from the tree (5). Its primary compound, honokiol, has been shown to reduce the time it takes to fall asleep by binding to GABA receptors in the brain, which help prompt sleep. A similar study in more than 600 menopausal women found that consuming a magnolia bark supplement daily for 12 weeks relieved symptoms of insomnia, irritability, and anxiety (32). Constant worry over money, job security, family, and health keeps your stress system on high alert all the time and it feels like you can never calm down. This makes sense, as its known that GABA(A) receptor activity is closely associated with sleep (29). The bark then undergoes a process of drying and boiling before its infused into a tincture for oral consumption. The supplement can be found at many online and retail stores. Experimental & molecular medicine, 40(6), 617628. Magnolia bark appears to have many potential benefits, including anticancer properties, improved sleep, treatment of menopause symptoms, relief of stress and anxiety, and protection against oxidation and inflammation. Below are the top researched-backed magnolia bark benefits for health. The Best Supplements for Healthy Digestion, How to Get the Protective Power of Vitamin K, Anti-inflammatory: able to reduce inflammation in the body, Antimicrobial: able to kill or slow the spread of bacteria, viruses, and fungi, Antioxidant: able to protect cells against damage by free radicals, Neuroprotective: able to protect brain cells against damage, Antidiabetic: able to control blood sugar and prevent diabetes, Antidepressant: able to reduce the symptoms of depression, Antiangiogenic: able to keep new blood vessels from forming and prevent tumor growth, Banxia Houpo Tang: This Chinese formula is said to move stagnant qi in the solar plexus, head, and throat area., Saiboku-To: This Japanese formula has anti-inflammatory properties that can help to reduce asthma symptoms.. What Is Elecampane Root, and Does It Have Benefits? The leaves and flowers from the tree are sometimes used as well. The buildup of fat around the liver is among the major causes of liver failure due to various reasons. Current microbiology, 77(9), 24132421. https://doi.org/10.1631/jzus.B1600299, Qu, W. M., Yue, X. F., Sun, Y., Fan, K., Chen, C. R., Hou, Y. P., Urade, Y., & Huang, Z. L. (2012). California Sycamore. Honokiol may be natures smart drug against cancer and other conditions; it works on numerous cellular and genetic pathways to halt cancer growth and metastasis, trigger apoptosis, reduce inflammation, decrease free radical formation and protect neurological function. Coping with stress is a full-time job, and your body needs all the support it can get. As always, make sure to consult your doctor before making any changes to your diet or adding a new supplement. Here is a closer look at some of the potential benefits of magnolia bark. When cortisol levels decrease, it suggests that overall stress has also decreased. Magnolia essential oil is known for stimulating the lymphatic system and helps in making the liver to function properly and help in toxins elimination. Exercising leads to the release of endorphins, natural feel-good chemicals that combat the effects of stress. Exception of use under qualified healthcare practitioner supervision. The combination was tested against an independent honokiol dose and an independent radiation dose. They produce aromatic, large, and attractive flowers that sometimes bloom up to 8 inches in diameter. Kuribara, H., Stavinoha, W. B., & Maruyama, Y. Research on honokiol has found that it can reduce inflammation in the brain and spinal cord specifically, partly due to its ability to cross the blood-brain barrier (14). In an 1869 medical text written by Dr. William Cook, he mentions that magnolia bark has relaxing qualities and can be used for someone who has nervous characteristics. Cancer acts with innate intelligence, like it has a mind of its own, and uses sophisticated mechanisms to survive at any cost. The first one is called Banxia Houpo Tang (Chinese) is a formula that helps move stagnant qi in the throat, head, and solar plexus area. Some of the conditions that magnolia bark has traditionally been used to treat include asthma, anxiety, depression, stomach disorders, and inflammation (3, 4). Honokiol: When stress and anxiety overwhelm your mind and your life, honokiol a compound extracted from magnolia bark offers quick, calming relief. One particular extract that exhibits remarkable ability against cancer is pure honokiol, a highly active molecule derived from Magnolia officinalis bark. Through many of the same mechanisms that it supports sleep by, magnolia bark can help reduce anxiety by activating receptors in the endocannabinoid system (like CBD) and reducing adrenaline and other stress hormones like cortisol. Magnolia bark is a powerful supplement prepared from the bark, leaves, and flowers of the houpo magnolia tree. The Therapeutic Effects of Magnolia Officinalis Extraction on an Antibiotics-Induced Intestinal Dysbacteriosis in Mice. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. Both the root and branch bark are used in therapeutic medicine. And since stress triggers galectin-3, the alarm protein, it also sets off inflammation even in your brain. When the danger passes, the system turns off and resets. The tree was later transported and cultivated in England. The scientific name of magnolia bark is Magnolia officinalis.The Chinese also call this herb "Houpu" referring to the thick (hou) bark that comes from the unadorned (pu) part of the tree. Researchers reviewed studies of pine pollen, and one study reported side effects of diarrhea, bloating, and loss of appetite. The dried bark is strong-smelling and slightly bitter. Honokiol was found to reduce anxiety levels in the mice without slowing down motor functions. This article reviews the science-supported benefits and side effects of magnolia bark. Active constituents in magnolia bark have shown in laboratory studies to have anti-tumor effects, and promote the death of cancerous cells. What if we could use our minds to reduce galectin-3? In both cultures, it has been used to encourage sleep, reduce inflammation, and support nervous disorders. Skip to content Resources Articles Body Systems Cancer Solutions Cardiovascular Health Digestive Health Immune System Breast Health Magnolia bark has traditionally been used to treat digestive problems, including abdominal bloating and pain, nausea, diarrhea, and loss of appetite. From these advancements, one thing has become crystal clear: In order to activate our innate healing abilities, to overcome cancer or any condition, we have to shift our biochemistry from a state of struggle and survival, to a state of harmony and wellness. Therefore, as long as magnolia bark is used responsibly, there do not appear to be many risks associated with its use. Along with these health benefits, the bark also has strong potential for weight loss, reducing inflammation, and improving sleep. However, the supplement used in these studies contained compounds other than magnolia bark. (2020). The bark of Magnolia oficinalis has been used in traditional Chinese medicine for centuries to address anxiety and nervous tension and to promote sleep. BioMed research international, 2021, 6688414. https://doi.org/10.1155/2021/6688414, Wang, Y. D., Sun, X. J., Yang, W. J., Li, J., & Yin, J. J. A 2019 review study found that honokiol has shown potential to prevent tumor growth in the brain, breast, colon, liver, and skin, among other organs (17). So learning how to manage your stress today may help protect you against that devastating loss of self in the future. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats. In a sleep study, honokiol was able to shorten the time it took for mice to fall asleep and increased the amount of time spent asleep. All rights reserved. The Botanical Institute does not provide medical advice, diagnosis, or treatment. At the same time, immune system under-reactions could leave you catching every cold, flu, or other bug thats going around. Yet again, clinical studies in humans need to be conducted. Healing Sleep: The Art and Science of Sleep. Siobhan is a herbal researcher and writer. I recently got some mulungu extract which I heard is the ultimate anxiety reducer but still waiting to try it because even taking a new supplement is anxiety inducing haha. Magnolol inhibited cancer growth and reduced tumor size in vitro. Chilampalli, S., Zhang, X., Fahmy, H., Kaushik, R. S., Zeman, D., Hildreth, M. B., & Dwivedi, C. (2010). Cissus quadrangularis: Uses, Benefits, Side Effects, and Dosage, Galangal Root: Benefits, Uses, and Side Effects. You may feel more worried, snap more easily, or have bigger emotional reactions than would normally match the situation youre in. 2005 - 2023 WebMD LLC, an Internet Brands company. When we address unhealthy galectin-3 expression with proven methods, we effectively treat not just cancer, but numerous life-threatening conditions as well. It is also commonly used to support gastrointestinal health. It also helps reduce brain inflammation, which has been closely linked with depression, anxiety, and other mood disorders. 2023 Dr. Axe. British journal of pharmacology, 167(3), 587598. Magnolol and honokiol achieve this effect by improving the intestinal movement that helps move digested food through the gastrointestinal tract. Multiple published papers on this unique extract demonstrate its effectiveness and safety, including one study showing it works synergistically with MCP. 220 A.D.). Are There Any Precautions to Consider While Taking Magnolia? WebMD does not provide medical advice, diagnosis or treatment. Our website content is for informational purposes only. The houpo magnolia tree is native to China, where it has been used for thousands of years as a supplement in traditional Chinese medicine. Note that the numbers in parentheses (1, 2, etc.) Its one of the top stress relievers out there. Journal of natural products, 72(1), 168171. This study also supports previous research showing that regular meditation reduces other pro-cancer proteins like TNF-alpha and CRP these inflammatory markers are triggered by the master regulator, galectin-3. Modified Citrus Pectin Formula - Dr. Isaac Eliaz The most advanced and effective solution for health, aging and longevityClinically Researched Modified Citrus Pectin. Magnolia bark extract is readily available in pill form. In fact, eye-opening research shows a direct link between galectin-3 and depression, making this alarm protein a strong potential target in treating stress-related mental illness. Regular yoga practice helps regulate your nervous system and reduces the harmful effects of stress. Both shade and ornamental tree, the California sycamore is large and grows fast, so make sure that you have enough space in your property. Any third party offering or advertising on this website does not constitute an endorsement by Andrew Weil, M.D. Research shows we can. 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